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Anti-inflammatory Agents. Chemistry and Pharmacology by Robert A. Scherrer, Michael Whitehouse

By Robert A. Scherrer, Michael Whitehouse

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Salicylates (3-6 gm/day) or antimalarial drugs, such as chloroquine (250 mg/day) or hydroxychloroquine (200-400 mg/day), may be the only treatment needed if only arthritis and dermatitis are present. However, if there is any life-threatening involvement of the heart or central nervous 20 HAROLD E. PAULUS system, large doses of corticosteroid drugs (> 100 mg/day of prednisone) may be needed to prevent death. It should be noted that even when steroids have this dramatic effect, they are not really much more effective than salicylates in the sense that they, too, are incapable of curing the disease and, like the salicylates, treat only the symptoms.

Med. Chem. 15, 84. Juby, P. , Hudyma, T. , and Partyka, R. A. (1972). U. S. Patent 3,663,627 (to BristolMyers). Lands, W. E. , Letellier, P. , Rome, L. , and Vanderhoek, J. Y. (1973). Adv. Biosciences 9, 15. Lockie, L. M. (1972). In "Arthritis and Allied Conditions" (J. L. Hollander and D. J. , pp. 483-494. Lea & Febiger, Philadelphia, Pennsylvania. , Ferreira, S. , and Vane, J. R. (1972). Int. Congr. Pharmacol. 5th, 1972 Abstract No. 959. Niemegeers, C. J. , Verbruggen, F. , and Janssen, P. A.

Winder et al. (1967). c Gittos and James (1970). rf Alpermann (1970). e Soldi et al. (1969). ^K. F. Swingle (unpublished). *Westby and Barfknecht (1973). A Too low compared with reference agents. 'Carrano and Malbica (1972). 'Mörsdorf and Wolf (1972). *DeMarchieia/. (1968). (1968). m Gryglewski et al. (1969). "Fujihira et al. (1971). "Flower** a/. (1972). 'Izard-Verchere et al. (1971). *Ham etal. (1972). r Niemegeers et al. (1964). b In contrast to the UV results, Sota et al. (1969) found that in the carrageenan assay there was little difference in activity between isomeric nitro, methyl, or methoxy derivatives.

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