By Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.
Edited by means of one of many world's top interventional cardiologists and educators, this new ebook is created with an eye fixed on giving the reader a high-quality, functional and clinically-focused knowing of this crucial classification of substances, from simple technology to a clear-headed dialogue of advanced themes similar to mixture remedies, drug-drug interactions, and platelet resistance.
This very important new book:
- Begins with a concise yet thorough dialogue of platelet biology and pathophysiology in order that readers know the way those cures paintings and why they could additionally produce this sort of diverse variety of problems, from minor gastrointestinal disillusioned, to almost certainly life-threatening stipulations resembling neutropenia, a serious scarcity of white blood cells.
- Thoroughly covers platelet functionality checking out, together with new, novel techniques.
- Clarifies present best-practices in regards to the use of antiplatelet brokers in either persistent and acute cardiovascular disease
- Reviews of all kinds of antiplatelet brokers – from aspirin to lately authorized medicines – together with symptoms, medical results, and facet effects/complications
Written via a global who's-who of specialists within the box, Antiplatelet treatment additionally comprises a complete part masking using antiplatelet medicines in PCIs, together with percutaneous valve fix, which makes this article quite necessary to Interventional Cardiologists.
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Edited through one of many world's top interventional cardiologists and educators, this new ebook is created with a watch on giving the reader a superb, sensible and clinically-focused realizing of this crucial type of substances, from simple technological know-how to a clear-headed dialogue of advanced subject matters similar to mixture cures, drug-drug interactions, and platelet resistance.
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Extra info for Antiplatelet Therapy in Cardiovascular Disease
8 Cattaneo, M. and Lecchi, A. (2007) Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin. Journal of Thrombosis and Haemostasis, 5, 577–582. , Carroll, K. et al. (2011) Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation, 124, 544–554. 19 20 Antiplatelet Therapy in Cardiovascular Disease 10 Cattaneo, M. (2010) New P2Y(12) inhibitors. Circulation, 121, 171–179.
The primary thrombin receptor on the platelet is the protease-activated receptor 1 (PAR-1). Thrombin directly activates the platelet through G protein-coupled receptors, leading to platelet aggregation and granule release . Unactivated platelets are unable to form thrombus, since they have almost no prothrombin expression on their surface . Apart from fibrinogen binding, GPIIb/IIIa receptors on nonstimulated platelets are also involved in binding of prothrombin, an interaction that increases the Platelet Receptors and Drug Targets: GP IIb/IIIa rate of prothrombin conversion to the activated thrombin.
Black dots mark the addition of 1 mM arachidonic acid. Actual ibuprofen plasma concentrations (HPLC) are also indicated. Platelet Receptors and Drug Targets: COX-1 Interaction between aspirin and naNSAIDs at the level of platelet COX-1 Low-dose aspirin cumulatively inactivates platelet COX-1 by acetylation of Ser530 within the substrate channel . Since naNSAIDs are attracted by overlapping binding sites in the COX substrate channel , one might expect that COX-1 inhibition by aspirin will be synergistically amplified.