Skip to content

Antiplatelet Therapy in Cardiovascular Disease by Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.

By Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.

Edited by means of one of many world's top interventional cardiologists and educators, this new ebook is created with an eye fixed on giving the reader a high-quality, functional and clinically-focused knowing of this crucial classification of substances, from simple technology to a clear-headed dialogue of advanced themes similar to mixture remedies, drug-drug interactions, and platelet resistance.

This very important new book:

  • Begins with a concise yet thorough dialogue of platelet biology and pathophysiology in order that readers know the way those cures paintings and why they could additionally produce this sort of diverse variety of problems, from minor gastrointestinal disillusioned, to almost certainly life-threatening stipulations resembling neutropenia, a serious scarcity of white blood cells.
  • Thoroughly covers platelet functionality checking out, together with new, novel techniques.
  • Clarifies present best-practices in regards to the use of antiplatelet brokers in either persistent and acute cardiovascular disease
  • Reviews of all kinds of antiplatelet brokers – from aspirin to lately authorized medicines – together with symptoms, medical results, and facet effects/complications

Written via a global who's-who of specialists within the box, Antiplatelet treatment additionally comprises a complete part masking using antiplatelet medicines in PCIs, together with percutaneous valve fix, which makes this article quite necessary to Interventional Cardiologists.

Show description

Read Online or Download Antiplatelet Therapy in Cardiovascular Disease PDF

Similar cardiovascular books

Percutaneous Interventions for Congenital Heart Disease

Written for pediatric cardiologists who are looking to concentrate on interventional cardiology and want a step by step consultant to conducting tactics, this useful textual content is usually aimed toward grownup cardiologists who are looking to research greater than simply 'shooting for the coronaries'. Addressing this desire, every kind of interventions in congenital center affliction and the recent box of 'structural center ailment' are coated, together with ·acquired valvular middle affliction ·post-myocardial infarction ventricular septal defects ·PFO closure ·closure of the left atrial appendage ·paravalvular leak closure ·techniques to regard illnesses of the aorta ·hybrid approaches the one fresh textual content on find out how to practice interventional cardiology for congenital middle sickness in either the pediatric and grownup sufferer, this expertly written paintings can assist to beat limitations among pediatric and grownup cardiologists, and pave the best way for a brand new expert, the cardiovascular interventionalist.

Hemophilia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

This can be a 3-in-1 reference publication. It supplies an entire scientific dictionary overlaying 1000s of phrases and expressions with regards to hemophilia. It additionally provides large lists of bibliographic citations. ultimately, it presents details to clients on how you can replace their wisdom utilizing a variety of web assets.

High-Risk Atherosclerotic Plaques: Mechanisms, Imaging, Models, and Therapy

Susceptible plaque improvement is the results of a posh sequence of molecular and mobile occasions regarding irritation, apoptosis, rupture, and thrombosis. a close realizing of the mechanisms underlying the improvement of high-risk plaques, besides the facility to imagine and diagnose those susceptible lesions, will result in the potent administration of acute coronary syndromes.

Antiplatelet Therapy in Cardiovascular Disease

Edited through one of many world's top interventional cardiologists and educators, this new ebook is created with a watch on giving the reader a superb, sensible and clinically-focused realizing of this crucial type of substances, from simple technological know-how to a clear-headed dialogue of advanced subject matters similar to mixture cures, drug-drug interactions, and platelet resistance.

Extra info for Antiplatelet Therapy in Cardiovascular Disease

Sample text

8 Cattaneo, M. and Lecchi, A. (2007) Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin. Journal of Thrombosis and Haemostasis, 5, 577–582. , Carroll, K. et al. (2011) Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation, 124, 544–554. 19 20 Antiplatelet Therapy in Cardiovascular Disease 10 Cattaneo, M. (2010) New P2Y(12) inhibitors. Circulation, 121, 171–179.

The primary thrombin receptor on the platelet is the protease-activated receptor 1 (PAR-1). Thrombin directly activates the platelet through G protein-coupled receptors, leading to platelet aggregation and granule release [9]. Unactivated platelets are unable to form thrombus, since they have almost no prothrombin expression on their surface [10]. Apart from fibrinogen binding, GPIIb/IIIa receptors on nonstimulated platelets are also involved in binding of prothrombin, an interaction that increases the Platelet Receptors and Drug Targets: GP IIb/IIIa rate of prothrombin conversion to the activated thrombin.

Black dots mark the addition of 1 mM arachidonic acid. Actual ibuprofen plasma concentrations (HPLC) are also indicated. Platelet Receptors and Drug Targets: COX-1 Interaction between aspirin and naNSAIDs at the level of platelet COX-1 Low-dose aspirin cumulatively inactivates platelet COX-1 by acetylation of Ser530 within the substrate channel [15]. Since naNSAIDs are attracted by overlapping binding sites in the COX substrate channel [16], one might expect that COX-1 inhibition by aspirin will be synergistically amplified.

Download PDF sample

Rated 4.67 of 5 – based on 3 votes