By Hansen, Steen; Pedersen-Bjergaard, Stig
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Extra resources for Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry
If a glucuronide metabolite is excreted by the gall, it may be hydrolyzed by bacterial ????-glucuronidase in the gut and then undergo reuptake in the body. Bioanalysis of feces is most often performed in relation to recovery studies of drug substances for the diagnosis of digestive disorders. Although being outside the human body, the content of the gut is considered to be the largest “organ” of the human body due to its bacterial activity, which can have an effect on the wellbeing of the person.
When racemic ibuprofen is given, the inactive R-ibuprofen will in vivo be converted to the active S-ibuprofen. When the active S-ibuprofen is given, no R-ibuprofen is formed. In guinea pigs, it has been shown that the S-cetirizine has a higher distribution to brain tissue than the R form due to a difference in plasma binding. In humans, the S-cetirizine has a higher excretion rate than the R form. Thus, it is important to be able to analyze the enantiomers separately. 2. 7). These molecules can be considered unique and will not have an enantiomer counterpart.
It is therefore easy to calculate the number of theoretical plates for a column. The number is dimensionless and the narrower the single peak, the more peaks can be separated. 4 Peak-to-valley ratio between two not fully resolved peaks where tR2 and tR1 are the retention of the last and the first elution peak, respectively. The peak width may be measured at baseline, w, or at half width, wh . Chromatographic computer software normally uses measurements at half height in their calculations. 2% is present.