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Biophysics by A. Misra

By A. Misra

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Congenital malformations with troubled flow dynamics: TGA = transposition of great arteries; TOF= tetralogy of Fallot; DORV, DOLV= double outlet right or left ventricle respectively. g. cardiogenic shock, multiple organ failure). This could be induced by disturbed flow dynamics due to pump failure and/or elevated vascular resistances. As a symbolic example, right ventricular (RV) failure can occur either due to elevated pulmonary vascular resistances caused by pulmonary oligemia, pulmonary hyperemia; or due to RV pump failure caused by ischemia, congenital anomalies, arrhythmia, valvulopathy, and/or accessory circulatory driving forces failure like with failed Fontan’s operation (Pereira & Shirali, 2005).

Zones Z1 Z2 Z3 Z4 Z5 Anatomical site SVC, IVC A-V cavity Septum Infundibulum PA tributary Remodeling Low Mild Normal High Low Main Factors Absence of shear rates  Steady flow Trabeculae Receiving interseptal left & right coronary supply  Coronary flow Pressure, Pulmonary Valve + Infudibulum Table 2. Right heart postnatal remodeling zones (Nour et al 2009): SVC, IVC: superior & inferior vena cava respectively; A-V: atrioventricular; PA: pulmonary artery. 3. Hemorheological stock: the right heart circuit contains > 64% of blood volume surrounded by an important mass of endothelial cells.

001). Pulse pressure was higher at P5 with position I, compared to position II & III. Pm was higher at P5 compared to NP with position I. B. com/ Table 5. Results of momentum energy losses, obtained in 3 different mock circuits. 42 Biophysics Fig. 16. Perfusions curves obtained in vitro Perfusion curves (in mmHg) obtained at different circuit sites in 3 different pulsatile Tube positions: I, II, III close & distant from aortic cannula and pre-oxygenator respectively. The perfusion curve amplitude was significantly higher at P5 with position I, compared to positions II & IIII.

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