By Gerald C. Timmis
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Extra resources for Cardiovascular Review 1983
Other studies (Circ 65:265, 82) caution that exercise testing did not correlate with coronary artery anatomy and failed to define a high risk subgroup. It does, however, correlate with the degree of net disease activity as defined by spontaneous attacks per day. Exercise ECG in the diagnosis of vasotonic angina is further discussed on p. 125. 2 ECHOCARDIOGRAPHY AND SCINTIGRAPHY: Methacholine given subcutaneously (6 mg) may produce asynergy as demonstrable on 2-dimensional echocardiography and with scintigraphy (AJC 43:329, 79).
Manthey et al. (Circ 64:722, 81) concluded that of the six essential minerals (magnesium, chromium, copper, manganese, selenium, and zinc), a deficiency in magnesium is the only abnormality which may be associated with severe CHD. Copper and manganese were also elevated in CHD but only if severe and hence were probably not pathogenetic. Contrary to previous reports, they found no deficiency of zinc or chromium. Cadmium (which causes CARDIOVASCULAR REVIEW 1983 23 uncoupling of oxidative phosphorylation) was found to be increased in proportion to cigarette smoking and thus may contribute to sudden death in smokers.
Zinc administration in man was shown by Hooper et al. (JAMA 244:1960, 80) to produce a sharp fall in "antiatherogenic" lipoprotein (HDL). Sherratt (Circ 63:247A, 81) suggested that magnesium deficiency which characterizes soft water may contribute to CHD and should be further explored. Manthey et al. (Circ 64:722, 81) concluded that of the six essential minerals (magnesium, chromium, copper, manganese, selenium, and zinc), a deficiency in magnesium is the only abnormality which may be associated with severe CHD.