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Ceramide Signaling by Anthony H. Futerman

By Anthony H. Futerman

The quantity assembles present details at the function of ceramide as a signalling molecule in sixteen chapters written by means of major employees during this region. particular awareness is given to mechanisms of research of ceramide and its biophysical houses, on enzymes of ceramide metabolism and down-stream ambitions of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the position of ceramide in neuronal signalling. ultimately, the publication closes with a piece at the healing implications of ceramide motion, within the components of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the aptitude clinical importance of delineating the jobs of ceramide in phone signalling. this can be the 1st quantity in particular dedicated to ceramide signalling, and may act as a useful source for uncomplicated and clinical researchers and graduate scholars wishing to get a state-of-the-art evaluate of this quickly relocating box.

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Molecular sorting of lipids by bacteriorhodopsin in dilauroylphosphatidylcholine/distearoylphosphatidylcholine lipid bilayers. Biophys J 1997; 73:1940-1953. 65. Lehtonen JYA, Holopainen JM, Kinnunen PKJ. Evidence for the formation of microdomains in liquid crystalline large unilamellar vesicles caused by hydrophobic mismatch of the constituent phospholipids. Biophys J 1996; 70:1753-1760. 66. Cremesti A, Paris F, Grassme H et al. Ceramide enables Fas to cap and kill. J Biol Chem 2001; 276:23954-23961.

55 Using DSC and NMR, Veiga et al48 further demonstrated that ceramide from egg yolk as well as from bovine brain promotes the formation of the inverted hexagonal (H II ) phase when added to liposomes composed of dielaidoylphosphatidylethanolamine (DEPE). 15), the La→HII transition temperature of DEPE decreased with no major changes in the transition enthalpy. The two ceramides did not differ in this respect although their acyl chain lengths varied considerably. 4 When the formation 14 Ceramide Signaling of a nonlamellar phase such as HII is not allowed, either due to high bending rigidity of the other leaflet of the bilayer or due to packing constraints (for instance, in small diameter vesicles with high positive curvature) there is a pronounced increase in the pressure within the hydrocarbon region of the bilayer.

49a Interestingly, variation in the N-acyl chain of ceramide affects the 2-D ordering of the DMPC/ceramide film. In brief, immiscibility of C16:0-ceramide is evident 12 Ceramide Signaling already at low content of this lipid. However, C24:1-ceramide in low content is miscible in DMPC, while either an increase in lateral pressure or the content of this ceramide induces immiscibility. This difference can be rationalized in terms of the long hydrocarbon chain of C24:1-ceramide protruding above the DMPC monolayer and causing an additional repulsive potential between the ceramides.

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